Liver problems. People with a history of hepatitis B or C virus or people who have certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function.

Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of your stomach area; itching.

Before you receive CABENUVA, tell your healthcare provider about all your medical conditions, including if you:

have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.

have ever had liver problems, including hepatitis B or C infection.

have ever had mental health problems.

are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.

are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

How will I receive CABENUVA?

Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.

Before receiving your first CABENUVA injections, your healthcare provider will have you take one VOCABRIA (cabotegravir) tablet and one EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how well you tolerate these medicines.

Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.

If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.

If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.