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Real Stories

Hear from real people about their experiences on CABENUVA

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People featured are compensated by ViiV Healthcare.

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ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?

CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

  • have ever had an allergic reaction to cabotegravir or rilpivirine.
  • are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

JAYSON and ONSCREEN TEXT:

Jayson:
My name is Jayson. I’m HIV positive. And I was diagnosed in 2001.

Text Onscreen:
Jayson
Stays undetectable with CABENUVA
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

JAYSON and ONSCREEN TEXT:

Jayson:
And I’ve always been proud of being a veteran.

Text Onscreen:
ViiV Healthcare paid him for his time and expenses in sharing his unique experience.

JAYSON:
I grew up in rural Maine. And so it was a way to get out of Maine, too; not to escape anything bad, but it was a ticket out.

ONSCREEN TEXT:
Diagnosis

JAYSON:
I remember when the doctor gave me the diagnosis…and by the time I got home, it had really kind of sunk in that okay, this is, you know, life-changing.

JAYSON and ONSCREEN TEXT:

Jayson:
My initial pill regimen for several years was one pill, once a day, usually at night.

Text Onscreen:
Jayson is living with HIV and taking CABENUVA at the time of filming.

JAYSON:
And that went on for a long, long time. And sometimes that pill is a big reminder of being HIV positive and this virus in your body.

ONSCREEN TEXT:
Learning about CABENUVA

JAYSON:
I’ve been on CABENUVA, and in my opinion, it’s been fantastic. It’s really nice not to have to rush home and take a pill. To not have to take pills anymore. That was huge. Once I knew there was something that you had a choice, I was like “sign me up.” For me, a quick change in plans on CABENUVA doesn’t mean anything. I don’t have to worry about it. I can continue on with what I was doing and adjust, and adapt, and take advantage of new opportunities that might come up because you missed the ferry, or you missed the plane, or whatever. And it is very flexible. For me, to feel that spontaneity on Saturday, or really any other day, it really is freedom. I don't have to think about what I'm gonna be doing later or do I have to be home. I can go out for dinner. I can meet friends out at the park, whatever it is. I don’t have to think about it at all because it’s Saturday. It’s not injection day.

JAYSON and ONSCREEN TEXT:

Jayson:
CABENUVA is two injections given by my healthcare provider every other month.

Text Onscreen:
Your doctor may have you take about a month of once-daily starter pills before beginning injections. Your every-other-month regimen begins after 2 months of injections.

JAYSON:
And so, it’s six times a year you go to the doctor. And it helps keep me undetectable.

JAYSON and ONSCREEN TEXT:

Jayson:
And so I know every eight weeks on a Tuesday, I’m gonna have my appointment. The appointment’s already set. I’m a planner. So, I plan it out and I know what I’m doing. It’s important to hit your target date, but if you can’t hit that date, you can hit it a week before to a week after.

Text Onscreen:
To help stay undetectable, it’s important to keep your planned appointments and stick with your treatment plan.

JAYSON:
So, it works out very well.

JAYSON and ONSCREEN TEXT:

Jayson:
And then, the injection itself really doesn’t take that long. It’s a relatively quick visit.

Text Onscreen:
Individual results may vary.

JAYSON:
It’s an office visit. It’s a chance – for me, I like the connection with the doctor, my doctor, and the medical staff. They get a chance to see you more with this, with this regimen. And so, like, “How are you feeling?” You know, “Is everything okay? What’s going on in your life?”

ONSCREEN TEXT:
Jayson on living life

JAYSON:
This is 20 years for me in August since I was diagnosed. And I’m gonna live to be an old man, probably, you know, hopefully. And so, it’s really, uhm, meaningful to me to leave a legacy for people who are HIV positive.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling lightheaded or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
  • Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

  • Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

  • have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
  • have ever had liver problems, including hepatitis B or C infection.
  • have ever had mental health problems.
  • are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take.
Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

  • Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
  • Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
  • Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
  • If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
  • If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220011 June 2022 Produced in USA.

View Video Transcript

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?

CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

  • have ever had an allergic reaction to cabotegravir or rilpivirine.
  • are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

ORLANDO:
My life is...

ORLANDO and ONSCREEN TEXT:

Orlando:
…kind of like a big personality. And so I need...

Text Onscreen:
Orlando is living with HIV and taking CABENUVA at the time of filming.

ORLANDO and ONSCREEN TEXT:

Orlando:
...To make sure that I have a wardrobe that can match that personality.

Text Onscreen:
ViiV Healthcare paid him for his time and expenses in sharing his unique experience.

ORLANDO:
I am an event planner and decorator, so I’m all about lines and intricate detail.

ORLANDO and ONSCREEN TEXT:

Orlando:
I’m Orlando. I am HIV positive. I was diagnosed in 2013.

Text Onscreen:
Orlando
Stays undetectable with CABENUVA
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

ONSCREEN TEXT:
Diagnosis

ORLANDO:
I remember after being diagnosed and watching the sunset, and that sun never rose. Every day it was the same moment of, “You have HIV.” I was 27 and here I am trying to figure out what it even meant to be gay.

ORLANDO and ONSCREEN TEXT:

Orlando:
I was told to take this pill every single day at the same time and if I didn’t my body may build a resistance.

Text Onscreen:
Resistance means that the HIV has adapted and some HIV medicines may no longer work.

ORLANDO:
If I’m out with my friends, working, or want to pick up an extra shift and I lose track of time, “Did you take your pill?” It was an everyday, constant reminder. Not just that I’m taking a pill, but, “Dude, you have HIV! This is your life for the rest of your life!”

ONSCREEN TEXT:
Learning about CABENUVA

ORLANDO:
I trusted everything that my doctors had been doing for me, so when I heard about it, I jumped right in.

ORLANDO and ONSCREEN TEXT:

Orlando:
It was the long-acting treatment that really got me to saying, “Hey, this is awesome for me!”

Text Onscreen:
Individual results may vary.

ORLANDO and ONSCREEN TEXT:

Orlando:
So now I take long-acting CABENUVA, and set my calendar and go to doctors. I receive two injections.

Text Onscreen:
Your doctor may have you take about a month of once-daily starter pills before beginning injections. Stay under the care of your doctor during treatment.

ORLANDO and ONSCREEN TEXT:

Orlando:
If I can’t make my target date, I have an opportunity to schedule that one week before or one week after.

Text Onscreen:
To help stay undetectable, it’s important to keep your planned appointments and stick with your treatment plan.

ORLANDO:
Now with the injection I don’t have to go to the pharmacist to fulfill a prescription. I don’t have to worry about, “Oh god! If I’m traveling, did I lose my pills?” I don’t have that daily pill regimen.

ONSCREEN TEXT:
Orlando on living life

ORLANDO:
I have a personality that announces itself. You know, I can hang out with my friends. I am genuinely free to just be who I am. I can focus on work. What I have is an opportunity to keep focusing on what’s important to me, and that is living life. And when I see how my clients light up when I have brought their image to life, there is a special place in my heart that warms up. That is almost what it felt like for me when I discovered CABENUVA.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling lightheaded or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
  • Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

  • Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

  • have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
  • have ever had liver problems, including hepatitis B or C infection.
  • have ever had mental health problems.
  • are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take. Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)

  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

  • Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
  • Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
  • Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
  • If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
  • If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220009 June 2022 Produced in USA.

View Video Transcript

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?

CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

  • have ever had an allergic reaction to cabotegravir or rilpivirine.
  • are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

MARK and ONSCREEN TEXT:

Mark:
I just turned 50, and I like to stay physical.

Text Onscreen:
Mark is living with HIV and taking CABENUVA at the time of filming.

MARK and ONSCREEN TEXT:

Mark:
I like to mountain bike. I like to hike.

Text Onscreen:
ViiV Healthcare paid him for his time and expenses in sharing his unique experience.

MARK and ONSCREEN TEXT:

Mark:
I’m Mark. I’m HIV positive, and I was diagnosed in 2006.

Text Onscreen:
Mark
Stays undetectable with CABENUVA
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

ONSCREEN TEXT:
Diagnosis

MARK:
I was 36 years old. I was probably in the best shape of my life at that time. I had a diagnosis that wasn’t going to be a death sentence for me. Knowing that HIV could be treated with medicine, I knew I’d survive this. And over the next 13 years I was prescribed a cocktail of 3 drugs. I would fill the pill dispenser Sunday, Monday, Tuesday, and Wednesday. I’d fill it for the week. It became a logistical nightmare. I was content to make it my problem for the rest of my life. I was really grateful for it, but I was just tired of taking a pill every day.

Text Onscreen:
Learning about CABENUVA

MARK and ONSCREEN TEXT:

Mark:
Now that I’m on CABENUVA, it’s refreshing to be on long-acting therapy. So, there was a transition for me. There was 1 month where I did the oral medications, and we were testing my reactions.

Text Onscreen:
Your doctor may have you take about a month of once-daily starter pills before beginning injections. Stay under the care of your doctor during treatment.

MARK:
So, at the 30-day mark, I had my first injection.

MARK and ONSCREEN TEXT:

Mark:
It was sore, I’ll admit, but the next day I’m not taking a pill. And now I get one injection of...

Text Onscreen:
In clinical studies, injection-site reactions were common. Most were mild to moderate. Results may vary.

MARK:
...cabotegravir and one injection of rilpivirine.

MARK and ONSCREEN TEXT:

Mark:
There is a target treatment date for the injections, but the next thing is there is a flexible week on either side.

Text Onscreen:
To help stay undetectable, it’s important to keep your planned appointments and stick with your treatment plan.

MARK:
So, if something happens at the doctor’s office or if I can’t get there because of work or anything, I do have that flexible time.

ONSCREEN TEXT:
Mark on living life

MARK and ONSCREEN TEXT:

Mark:
To be on long-acting CABENUVA, there is less on my mind, not worrying about trips to the pharmacy.

Text Onscreen:
Individual results may vary.

MARK:
I’ve been told I’m an optimist. I have learned that “yes” is a very powerful word and to say “yes” to a lot of opportunities. To do the things that I want to do and be outside and ride my bike with my friends. Just being able to laugh with friends is one of the best things, yeah.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling lightheaded or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
  • Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

  • Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

  • have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
  • have ever had liver problems, including hepatitis B or C infection.
  • have ever had mental health problems.
  • are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take. Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

  • Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
  • Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
  • Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
  • If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
  • If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220008 June 2022 Produced in USA.

View Video Transcript

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?

CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

  • have ever had an allergic reaction to cabotegravir or rilpivirine.
  • are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

KAREN:
You have to live life...

KAREN and ONSCREEN TEXT:

Karen:
…and be happy and be positive,…

Text Onscreen:
Karen is living with HIV and taking CABENUVA at the time of filming.

KAREN and ONSCREEN TEXT:

Karen:
…and that’s how I tend to live. My name is Karen and I have been...

Text Onscreen:
Karen
Stays undetectable with CABENUVA
Karen is living with HIV and taking CABENUVA at the time of filming.
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

KAREN and ONSCREEN TEXT:

Karen:
…living with HIV since 2016.

Text Onscreen:
Karen is living with HIV and taking CABENUVA at the time of filming.
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

ONSCREEN TEXT:
Diagnosis

KAREN and ONSCREEN TEXT:

Karen:
When I first got diagnosed, I didn’t know where to start.

Text Onscreen:
ViiV Healthcare paid her for her time and expenses in sharing her unique experience.

KAREN:
My best friend was a big help. She said, “hey, Karen, you know, it’s going to be okay,” you know, told me different places I can go to get the assistance I need. My daughter, amazing. She would go to the doctors with me, all my appointments. She really supports me 100%. You have to not allow it to defeat you, so that’s what I try to do.

ONSCREEN TEXT:
Learning about CABENUVA

KAREN:
I have a wonderful doctor, and when he told me about CABENUVA,…

KAREN and ONSCREEN TEXT:

Karen:
…I’m like, “you know what? That’ll probably work for me.”

Text Onscreen:
CABENUVA is for adults to replace their current HIV-1 treatment. Your doctor will determine if CABENUVA is right for you.

KAREN:
I have two jobs.

KAREN and ONSCREEN TEXT:

Karen:
Normally, when you take oral pills, you have to take them at the same time every day, and that would be hard with my lifestyle.

Text Onscreen:
Your doctor may have you take about a month of once-daily starter pills before beginning injections.
Stay under the care of your doctor during treatment.

KAREN:
On CABENUVA, it’s not a constant reminder that I have to remember to take my HIV pill every day.

KAREN and ONSCREEN TEXT:

Karen:
I get two injections. They let me know it’s time for me to come in to get my injection.

Text Onscreen:
You may be asked to wait 10 minutes following your injection. After that, you should be able to resume your daily activities.

KAREN:
If I can’t make that date, I’ll call them, and say, “Hey, I can’t come in, can you move it to another date?” I have a week prior and a week after...

KAREN and ONSCREEN TEXT:

Karen:
…to actually get the injection. To be able to have that window is amazing for me and it works for me.

Text Onscreen:
It is important that you attend your planned injection appointments. Stay under the care of a healthcare provider during treatment with CABENUVA.

ONSCREEN TEXT:
Karen on living life

KAREN:
Life goes on. I try to have positive energy with the help of my friends and my family, and I do my best to try to help as many people as I can. You just never know what people are going through. This is not the end of the world. You don’t have to stop your dreams. You can keep doing the things that you’ve always wanted to do. Life is a gift. I try to live it to the fullest, and, haha, I’m good.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling lightheaded or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
  • Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

  • Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

  • have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
  • have ever had liver problems, including hepatitis B or C infection.
  • have ever had mental health problems.
  • are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take. Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

  • Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
  • Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
  • Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
  • If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
  • If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220007 June 2022 Produced in USA.

View Video Transcript

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?

CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

  • have ever had an allergic reaction to cabotegravir or rilpivirine.
  • are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

STEVE and ONSCREEN TEXT:

Steve:
I’ve come light-years from where I was five and a half years ago to today.

Text Onscreen:
Steve is living with HIV and taking CABENUVA at the time of filming.

STEVE and ONSCREEN TEXT:

Steve:
It’s been an amazing journey. My name is Steve.

Text Onscreen:
Steve
Stays undetectable with CABENUVA
Undetectable means the amount of HIV in the blood measures less than 50 copies per mL. Individual results may vary.

ONSCREEN TEXT:
Diagnosis

STEVE and ONSCREEN TEXT:

Steve:
I think early on, especially when I was first diagnosed, I had a lot of internal stigma around...

Text Onscreen:
ViiV Healthcare paid him for his time and expenses in sharing his unique experience.

STEVE:
...living with HIV. I was able to, really through my doctors, through my medical team, work my way through that, see that I was going to be okay. I could still have a successful and long life, and be happy.

ONSCREEN TEXT:
Learning about CABENUVA

STEVE:
When I was on the daily pills, I was not out about my HIV status. So, anytime I would go to visit family or friends, there’s also this fear too. Is someone going to see my pills? Am I going to leave my pill bottle out? I did travel internationally for work a lot at that time, and so constantly this fear of, did I pack everything? Am I going to get pulled aside in customs? Are they going to start asking questions about what these pills are? Until I got on to CABENUVA, and the long-acting injections I didn’t really fully appreciate the toll that it was having that daily reminder and the fear around my pills being discovered.

That’s one of the benefits that I found in my experience with using CABENUVA is the ability to get the two injections and not have to worry about did I forget my pill bottles? Am I going to be able to get my refills?

STEVE and ONSCREEN TEXT:

Steve:
There might be a one-month lead-in before you start the injections where you’re taking two daily pills with the active ingredients that make up CABENUVA. And really the point of that is to...

Text Onscreen:
Your doctor may have you take about a month of once-daily starter pills before beginning injections. Stay under the care of your doctor during treatment.

STEVE:
...make sure that your body’s going to tolerate the medication.

STEVE and ONSCREEN TEXT:

Steve:
You do have a target date that you want to hit to make sure that you have the kind of ideal amount of medicine in your system.

Text Onscreen:
It is important that you attend your planned injection appointments. Stay under the care of a healthcare provider during treatment with CABENUVA.

STEVE and ONSCREEN TEXT:

Steve:
There is a window on either side of that, that allows you to be flexible, with the idea of wanting to hit that target date.

Text Onscreen:
It is important that you attend your planned injection appointments. There is a Flexible Treatment Window–from 7 days before to 7 days after the Target Treatment Date.

ONSCREEN TEXT:
Steve on living life

STEVE:
I really like to stay active, stay outdoors. I like to hike. I like to go out on the boat, with my friends, and my boyfriend, swim in the lake. I think that HIV has actually changed my life for the positive in some ways. It forced me to kind of reconcile some of the beliefs that I was brought up with—to be more open about who I was. My diagnosis allowed me to be open and live my true life.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling lightheaded or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

  • Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
  • Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

  • Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

  • Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

  • have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
  • have ever had liver problems, including hepatitis B or C infection.
  • have ever had mental health problems.
  • are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take. Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

  • Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
  • Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
  • Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
  • If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
  • If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL)
extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220004 May 2022 Produced in USA.

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