Getting Started
on CABENUVA

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL) extended-release injectable suspensions

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 pounds. It is used as a replacement for their current HIV-1 medicines when their doctor determines it’s right for them.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you are allergic to any of its ingredients, or if you are taking certain medicines.
Watch the complete video for more safety information.

Text Onscreen:
What is CABENUVA?
CABENUVA is a complete prescription regimen used to treat HIV-1 infection in people 12 years and older who weigh at least 77 lbs (35 kg), to replace their current HIV-1 medicines when their healthcare provider determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION
Do not receive CABENUVA if you:

• have ever had an allergic reaction to cabotegravir or rilpivirine.
• are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; dexamethasone (more than a single-dose treatment); St John’s wort (Hypericum perforatum).

Watch the complete video for more safety information. Please see the full Prescribing Information, including Patient Information, at CABENUVA.com

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Hello. So, you’re considering switching your…

Text Onscreen:
Hello

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…HIV treatment to CABENUVA, an injectable treatment that’s designed…

Text Onscreen:
CABENUVA LOGO

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…to help you stay undetectable. Here’s what to expect along the way.

Text Onscreen:
Helps you stay undetectable
Undetectable means the amount of HIV in the blood is below the level that can be measured by a lab test. Results may vary.

ANNOUNCER:
Getting to CABENUVA goes like this:

ANNOUNCER and ONSCREEN TEXT:
READY…SET…GO!

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Let’s talk about the first step.

Text Onscreen:
CLINIC

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Ready!

Text Onscreen:
READY
Verify coverage and costs

ANNOUNCER and ONSCREEN TEXT:

Announcer:
If your doctor prescribes CABENUVA, your doctor’s office and ViiVConnect can help verify your insurance and medication coverage.

Text Onscreen:
ViiVCONNECT LOGO
ViiV HEALTHCARE LOGO

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Once the enrollment form is submitted, your doctor’s office can help you understand any potential out-of-pocket costs for CABENUVA.

Text Onscreen:
ViiVCONNECT LOGO
ViiV HEALTHCARE LOGO
Doctor’s Office

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When they call you, be sure to ask about…

Text Onscreen:
CLINIC

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Your Medication Coverage

Text Onscreen:
Your Medication Coverage

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Copays for injection appointments

Text Onscreen:
Copays For Injection Appointments

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…and savings programs you might be eligible for.

Text Onscreen:
Savings Programs

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Remembering to ask about these three things can help give you a better understanding of your out-of-pocket costs for CABENUVA.

Text Onscreen:

1. Coverage
2. Copays
3. Savings Programs

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Next stop, Set! Before your first CABENUVA injections you and your doctor will set up your treatment plan...

Text Onscreen:
SET
Prepare for your treatment plan

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…and schedule your first appointment.

Text Onscreen:
Schedule your first injection appointment

ANNOUNCER and ONSCREEN TEXT:

Announcer:
This day will become your ongoing Target Treatment Date, so choose a date that works for you regularly, as it’s important to keep your appointments around this date.

Text Onscreen:
Target Treatment Date
CABENUVA injections can be given once a month or every-other-month.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before starting CABENUVA, your doctor may have you take about a month of once-daily starter pills to see how your body reacts to...

Text Onscreen:
Your doctor may have you take starter pills for about a month before your first injections

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…the 2 medicines in CABENUVA.

Text Onscreen:
VOCABRIA (cabotegravir) 30-mg tablets
EDURANT (rilpivirine) 25-mg tablets

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Your starter pills will come in a Welcome Pack that will be delivered to you or your doctor’s office.

Text Onscreen:
Your Welcome Pack
Delivered to you. Or your doctor.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Now, it’s “GO” time!

Text Onscreen:
GO!
Begin long-acting treatment

ANNOUNCER:
You’ll take your last dose of daily HIV pills on the same day as your first CABENUVA appointment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Here is what you can expect on that day.

Text Onscreen:
Doctor

ANNOUNCER:
During your treatment appointment,…

ANNOUNCER and ONSCREEN TEXT:

Announcer:
...a trained healthcare professional will give you two injections,...

Text Onscreen:
Two Injections

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…one in each side of your buttocks.

Text Onscreen:
In clinical studies, injection-site reactions were common. Most were mild to moderate. Results may vary.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Each injection contains one of the two medicines in CABENUVA.

Text Onscreen:
Cabotegravir
Rilpivirine
In clinical studies, injection-site reactions were common. Most were mild to moderate. Results may vary.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
These medicines work to help you stay undetectable.

Text Onscreen:
Cabotegravir
Rilpivirine
Results may vary.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Following your injections, you may be asked to wait about 10 minutes. After that, you should be able to resume your daily activities,…

Text Onscreen:
1-10 minutes
Results may vary.

ANNOUNCER:
…but always check with your doctor.

ANNOUNCER:
You’ll get your CABENUVA injections on or around your…

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…Target Treatment Date, that you and your doctor chose. If you can’t make your regular appointment date,...

Text Onscreen:
Target Treatment Date

ANNOUNCER and ONSCREEN TEXT:

Announcer:
…you have a Flexible Treatment Window from 7 days before to 7 days after your Target Treatment Date.

Text Onscreen:
Flexible Treatment Window

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Your first and second injection appointments will be one month apart.

Text Onscreen:
One month apart

ANNOUNCER and ONSCREEN TEXT:

Announcer:
After that, you will begin your monthly or every-other-month regimen.

Text Onscreen:
Monthly or every-other-month

ANNOUNCER and ONSCREEN TEXT:

Announcer:
It is important to keep your planned appointments and to contact your doctor right away if you can’t make your Target Treatment Date.

Text Onscreen:
APPOINTMENT REMINDER
CALLING…DOCTOR

ANNOUNCER:
You’ve come this far with daily HIV pills.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Your regular CABENUVA injections can help you stay undetectable.

Text Onscreen:
Results may vary.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Your doctor can be a good source of information to help guide you through the process. So, ask and learn. It’s all part of getting to CABENUVA.

Text Onscreen:
GOOD2GO

ONSCREEN TEXT:
CABENUVA LOGO
Keep watching for more Important Safety Information about CABENUVA.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
CABENUVA may cause serious side effects, including allergic reactions. Call your healthcare provider right away if you develop a rash. Stop receiving CABENUVA and get medical help right away if, along with a rash, you have a fever, feel generally ill or tired, have muscle or joint aches, have trouble breathing, have blisters or blisters or sores in the mouth, have redness or swelling of the eyes, or have swelling of the mouth, face, lips, or tongue.
Post-injection reactions have happened within minutes after rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include trouble breathing, narrowing of airways, stomach cramps, sweating, numbness of the mouth, pain in areas such as the back and chest, feeling anxious, feeling warm, rash, feeling light-headed or faint, and blood pressure changes.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA?
CABENUVA may cause serious side effects, including:

• Allergic reactions. Call your healthcare provider right away if you develop a rash with CABENUVA. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.
• Post-injection reactions have happened in some people within minutes after receiving their rilpivirine injection. Most symptoms resolved within minutes. Symptoms may include: trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of the mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or faint; blood pressure changes.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
During CABENUVA treatment, people who have a history of hepatitis B or C or have certain liver function test changes may be at increased risk of liver problems and new or worsening changes in certain liver tests. Liver problems have also happened in people with no history of liver problems or other risk factors. Call your healthcare provider right away if you develop signs or symptoms of liver problems, including the skin or the white part of the eyes turning yellow, dark or “tea-colored” urine, light-colored stools, nausea or vomiting, loss of appetite, pain, aching, or tenderness on the right side of the stomach area, and itching.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

• Liver problems. People with a history of hepatitis B or C virus or with certain liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests during CABENUVA treatment. Liver problems have also happened in people without history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: the skin or the white part of the eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of the stomach area; itching.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Depression or mood changes may occur. Call your healthcare provider or get emergency medical help right away if you feel sad or hopeless, anxious or restless, or have thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects are injection site reactions, fever, tiredness, headache, muscle or bone pain, nausea, sleep problems, dizziness, and rash. Injection site reaction symptoms include pain, tenderness, and others listed here.
These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
What are the possible side effects of CABENUVA? (cont’d)
CABENUVA may cause serious side effects, including: (cont’d)

• Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of CABENUVA include:

• Pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site; fever; tiredness; headache; muscle or bone pain; nausea; sleep problems; dizziness; rash.

These are not all the possible side effects of CABENUVA. Call your doctor for medical advice about side effects.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Before receiving CABENUVA, tell your healthcare provider about all your medical conditions, including if you have ever had a rash or allergic reaction to medicines containing cabotegravir or rilpivirine, liver problems including hepatitis B or C infection, or mental health concerns.
Tell your healthcare provider if you are, or plan to become, pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
Also tell your healthcare provider if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA because it isn’t known if CABENUVA can pass to your baby in your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA
Tell your healthcare provider about all your medical conditions, including if you:

• have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir or rilpivirine.
• have ever had liver problems, including hepatitis B or C infection.
• have ever had mental health problems.
• are pregnant or plan to become pregnant. It is not known if CABENUVA will harm your unborn baby. CABENUVA can remain in your body for up to 12 months or longer after the last injection.
• are breastfeeding or plan to breastfeed. Do not breastfeed if you take CABENUVA. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if CABENUVA can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby during treatment.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
Tell your healthcare provider about all medicines, vitamins, and herbal supplements you take. Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
Before receiving CABENUVA (cont’d)
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

• Some medicines interact with CABENUVA. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
When receiving CABENUVA once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections, 1 into the muscle of each side of your buttocks.
Before your first CABENUVA injections, your doctor may have you take 1 VOCABRIA tablet and 1 EDURANT tablet once a day for 1 month to assess how you tolerate these medicines.
Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments. If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
If you stop CABENUVA treatment, you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
How will I receive CABENUVA?

• Once a month or once every 2 months, a healthcare provider will inject CABENUVA as 2 injections (cabotegravir and rilpivirine), one into the muscle of each side of your buttocks.
• Before receiving your first CABENUVA injections, your healthcare provider may have you take 1 VOCABRIA (cabotegravir) tablet and 1 EDURANT (rilpivirine) tablet once a day for 1 month (at least 28 days) to assess how you tolerate these medicines.
• Stay under the care of a healthcare provider during CABENUVA treatment. It is important that you attend all planned injection appointments.
• If you miss or plan to miss a scheduled CABENUVA injection by more than 7 days, call your healthcare provider right away to discuss your treatment options.
• If you stop treatment with CABENUVA you will need to take other medicines to treat your HIV-1 infection and reduce the risk of developing viral resistance. Call your healthcare provider right away to discuss your treatment options.

ANNOUNCER and ONSCREEN TEXT:

Announcer:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

Text Onscreen:
IMPORTANT SAFETY INFORMATION (cont’d)
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the Patient Information for CABENUVA and discuss it with your healthcare provider.

ONSCREEN TEXT:
CABENUVA (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL) extended-release injectable suspensions
ViiV HEALTHCARE LOGO
Trademarks are property of their respective owners.
©2022 ViiV Healthcare or licensor. CBRVID220005 June 2022 Produced in USA.